Slay the Spire 2 Card Guide

Synthesis

Deal 12 damage. The next Power you play costs 0 .

Character
Defect
Type
Attack
Cost
2
Rarity
Uncommon

Should You Pick Synthesis?

This card becomes valuable when your run already supports its mechanic. Without the proper synergy density, it can slow down early deck development.

When to Pick

  • When your build already supports this mechanic
  • When you need scaling damage
  • When the card fits your draft direction

When to Skip

  • When your deck lacks synergy support
  • When it slows early combat
  • When it competes with stronger scaling cards

Builds That Use Synthesis

poison exhaust attack-combo

Related Relics & Potions

Relics that enhance this card Potions that support this strategy

Synthesis FAQ

Is Synthesis a good card in Slay the Spire 2?

It depends on your deck direction. Cards are strongest when their mechanic is supported by relics and other cards.