Slay the Spire 2 Synergies
Browse shared mechanics across cards, relics, and potions to understand which synergies already support real build directions in Early Access.
See how the same mechanic shows up across cards, relics, and potions.
Use synergy tags to discover which mechanics are mature enough to support real build directions.
Move from a mechanic tag into build pages, relic pages, and potion pages with more context.
A lot of early build planning is really mechanic planning. Before a deck becomes a full build, it usually starts as a shared synergy — poison, exhaust, discard, orb value, strength scaling, or repeated attack triggers.
This page exists to help you see which mechanics already have enough support across cards, relics, and potions to feel real, and which mechanics are still present but thin. That makes it more useful than a flat tag index and more flexible than a strict build list.
Primary Synergy Directions
Mechanics most likely to support real build planning
Poison
Explore how poison connects cards, relics, potions, and build directions in Early Access.
Exhaust
Explore how exhaust connects cards, relics, potions, and build directions in Early Access.
Discard
Explore how discard connects cards, relics, potions, and build directions in Early Access.
Orb
Explore how orb connects cards, relics, potions, and build directions in Early Access.
Strength
Explore how strength connects cards, relics, potions, and build directions in Early Access.
Attack Combo
Explore how attack combo connects cards, relics, potions, and build directions in Early Access.
If your run feels unclear, mechanic hubs are often the easiest way to understand what your resources are pointing toward.
A mechanic is much more useful when it shows up across multiple resource layers instead of only one.
Use synergy pages to move into more complete build guides when the mechanic starts looking coherent.
Secondary / Experimental Synergies
Useful tags, but not all of them are equally mature as standalone directions
Accuracy
Explore how accuracy connects cards, relics, potions, and build directions in Early Access.
Afterimage
Explore how afterimage connects cards, relics, potions, and build directions in Early Access.
Arsenal
Explore how arsenal connects cards, relics, potions, and build directions in Early Access.
Biased Cognition
Explore how biased cognition connects cards, relics, potions, and build directions in Early Access.
Black Hole
Explore how black hole connects cards, relics, potions, and build directions in Early Access.
Block
Explore how block connects cards, relics, potions, and build directions in Early Access.
Buffer
Explore how buffer connects cards, relics, potions, and build directions in Early Access.
Calcify
Explore how calcify connects cards, relics, potions, and build directions in Early Access.
Card Draw
Explore how card draw connects cards, relics, potions, and build directions in Early Access.
Card Generation
Explore how card generation connects cards, relics, potions, and build directions in Early Access.
Consuming Shadow
Explore how consuming shadow connects cards, relics, potions, and build directions in Early Access.
Coolant
Explore how coolant connects cards, relics, potions, and build directions in Early Access.
Countdown
Explore how countdown connects cards, relics, potions, and build directions in Early Access.
Crimson Mantle
Explore how crimson mantle connects cards, relics, potions, and build directions in Early Access.
Cruelty
Explore how cruelty connects cards, relics, potions, and build directions in Early Access.
Damage
Explore how damage connects cards, relics, potions, and build directions in Early Access.
Danse Macabre
Explore how danse macabre connects cards, relics, potions, and build directions in Early Access.
Debilitate
Explore how debilitate connects cards, relics, potions, and build directions in Early Access.
Defend
Explore how defend connects cards, relics, potions, and build directions in Early Access.
Devour Life
Explore how devour life connects cards, relics, potions, and build directions in Early Access.
Dexterity
Explore how dexterity connects cards, relics, potions, and build directions in Early Access.
Disintegration
Explore how disintegration connects cards, relics, potions, and build directions in Early Access.
Doom
Explore how doom connects cards, relics, potions, and build directions in Early Access.
Energy
Explore how energy connects cards, relics, potions, and build directions in Early Access.
Envenom
Explore how envenom connects cards, relics, potions, and build directions in Early Access.
Eternal
Explore how eternal connects cards, relics, potions, and build directions in Early Access.
Ethereal
Explore how ethereal connects cards, relics, potions, and build directions in Early Access.
Feral
Explore how feral connects cards, relics, potions, and build directions in Early Access.
Focus
Explore how focus connects cards, relics, potions, and build directions in Early Access.
Hailstorm
Explore how hailstorm connects cards, relics, potions, and build directions in Early Access.
Inferno
Explore how inferno connects cards, relics, potions, and build directions in Early Access.
Innate
Explore how innate connects cards, relics, potions, and build directions in Early Access.
Intangible
Explore how intangible connects cards, relics, potions, and build directions in Early Access.
Iteration
Explore how iteration connects cards, relics, potions, and build directions in Early Access.
Juggernaut
Explore how juggernaut connects cards, relics, potions, and build directions in Early Access.
Knockdown
Explore how knockdown connects cards, relics, potions, and build directions in Early Access.
Lethality
Explore how lethality connects cards, relics, potions, and build directions in Early Access.
Lightning Rod
Explore how lightning rod connects cards, relics, potions, and build directions in Early Access.
Mind Rot
Explore how mind rot connects cards, relics, potions, and build directions in Early Access.
Minion
Explore how minion connects cards, relics, potions, and build directions in Early Access.
Neurosurge
Explore how neurosurge connects cards, relics, potions, and build directions in Early Access.
Osty
Explore how osty connects cards, relics, potions, and build directions in Early Access.
Ostyattack
Explore how ostyattack connects cards, relics, potions, and build directions in Early Access.
Outbreak
Explore how outbreak connects cards, relics, potions, and build directions in Early Access.
Parry
Explore how parry connects cards, relics, potions, and build directions in Early Access.
Phantom Blades
Explore how phantom blades connects cards, relics, potions, and build directions in Early Access.
Plating
Explore how plating connects cards, relics, potions, and build directions in Early Access.
Prep Time
Explore how prep time connects cards, relics, potions, and build directions in Early Access.
Retain
Explore how retain connects cards, relics, potions, and build directions in Early Access.
Rolling Boulder
Explore how rolling boulder connects cards, relics, potions, and build directions in Early Access.
Self Hp Loss
Explore how self hp loss connects cards, relics, potions, and build directions in Early Access.
Sentry Mode
Explore how sentry mode connects cards, relics, potions, and build directions in Early Access.
Serpent Form
Explore how serpent form connects cards, relics, potions, and build directions in Early Access.
Shiv
Explore how shiv connects cards, relics, potions, and build directions in Early Access.
Sic Em
Explore how sic em connects cards, relics, potions, and build directions in Early Access.
Signal Boost
Explore how signal boost connects cards, relics, potions, and build directions in Early Access.
Sleight Of Flesh
Explore how sleight of flesh connects cards, relics, potions, and build directions in Early Access.
Sloth
Explore how sloth connects cards, relics, potions, and build directions in Early Access.
Sly
Explore how sly connects cards, relics, potions, and build directions in Early Access.
Smokestack
Explore how smokestack connects cards, relics, potions, and build directions in Early Access.
Sneaky
Explore how sneaky connects cards, relics, potions, and build directions in Early Access.
Soul
Explore how soul connects cards, relics, potions, and build directions in Early Access.
Speedster
Explore how speedster connects cards, relics, potions, and build directions in Early Access.
Spinner
Explore how spinner connects cards, relics, potions, and build directions in Early Access.
Star Next Turn
Explore how star next turn connects cards, relics, potions, and build directions in Early Access.
Storm
Explore how storm connects cards, relics, potions, and build directions in Early Access.
Strangle
Explore how strangle connects cards, relics, potions, and build directions in Early Access.
Strike
Explore how strike connects cards, relics, potions, and build directions in Early Access.
Sword Sage
Explore how sword sage connects cards, relics, potions, and build directions in Early Access.
Thorns
Explore how thorns connects cards, relics, potions, and build directions in Early Access.
Thunder
Explore how thunder connects cards, relics, potions, and build directions in Early Access.
Unplayable
Explore how unplayable connects cards, relics, potions, and build directions in Early Access.
Vigor
Explore how vigor connects cards, relics, potions, and build directions in Early Access.
Void Form
Explore how void form connects cards, relics, potions, and build directions in Early Access.
Vulnerable
Explore how vulnerable connects cards, relics, potions, and build directions in Early Access.
Waste Away
Explore how waste away connects cards, relics, potions, and build directions in Early Access.
Weak
Explore how weak connects cards, relics, potions, and build directions in Early Access.
Wraith Form
Explore how wraith form connects cards, relics, potions, and build directions in Early Access.
A wiki tag page usually just groups names by keyword. This hub tries to answer a more useful question: does this mechanic have enough ecosystem support to matter in real deck decisions?
That is why each synergy card shows counts across cards, relics, and potions. The point is not just to index mechanics, but to help you understand how much real support each one currently has in Early Access.
Synergy FAQ
What is a synergy page in Slay the Spire 2?
A synergy page groups resources around a shared mechanic, then shows how that mechanic appears across cards, relics, potions, and build directions.
How is this different from a build page?
A build page explains a full direction. A synergy page explains the shared mechanic underneath that direction and connects all the related resources.
Why does this matter in Early Access?
Because the full meta is still incomplete. Mechanic hubs help you understand what already has enough ecosystem support and what is still too thin to rely on.
Related Decision Hubs
Move from shared mechanics into full build directions supported by cards, relics, and potions.
See which relics reinforce each mechanic and which ones change build planning the most.
Explore tactical potions that align with specific mechanics and combat plans.
Use your current deck to identify which build or mechanic your run is drifting toward.