Slay the Spire 2 Card Guide

Neutralize

Deal 3 damage. Apply 1 Weak.

Character
Silent
Type
Attack
Cost
0
Rarity
JorbsGood old Neutralize. Neutralize does okay in Act 1 and sometimes remains relevant because of its weak application later in the game. You can upgrade it if you want, but you can also try to aim higher than that.

Should You Pick Neutralize?

This card becomes valuable when your run already supports its mechanic. Without the proper synergy density, it can slow down early deck development.

When to Pick

  • When your build already supports this mechanic
  • When you need scaling damage
  • When the card fits your draft direction

When to Skip

  • When your deck lacks synergy support
  • When it slows early combat
  • When it competes with stronger scaling cards

Builds That Use Neutralize

poison exhaust attack-combo

Related Relics & Potions

Relics that enhance this card Potions that support this strategy

Neutralize FAQ

Is Neutralize a good card in Slay the Spire 2?

It depends on your deck direction. Cards are strongest when their mechanic is supported by relics and other cards.